联用奥美拉唑与阿莫西林治疗胃炎合并胃溃疡的最新进展

Abstract: Gastritis and gastric ulcer are common digestive system diseases, with helicobacter pylori (Hp) infection being the primary pathogenic factor. In recent years, the combined regimen of omeprazole and amoxicillin has garnered significant attention due to its notable synergistic effects. This article reviews the pharmacological properties of omeprazole (a proton pump inhibitor) and amoxicillin (a β-lactam antibiotic), the advantages of combination therapy, and recent clinical research progress. Multiple randomized controlled trials have demonstrated that combination therapy significantly improves Hp eradication rates, shortens symptom control duration, and reduces relapse risk. Although challenges such as drug resistance and long-term medication safety persist, current evidence supports this regimen as a first-line treatment option for Hp-associated gastritis and gastric ulcer. Future efforts should focus on optimizing medication strategies and exploring personalized treatment approaches.