维生素 D 联合地特胰岛素治疗妊娠期糖尿病的有效性分析

Objective To investigate the clinical efficacy of vitamin D (Vit D) combined with insulin detemir in the treatment of gestational diabetes mellitus (GDM). Methods A total of 70 GDM patients treated in our hospital from October 2022 to October 2024 were selected and randomly divided into two groups using a random number table, with 35 patients in each group. The control group received treatment with insulin detemir, while the observation group received combined treatment with Vit D on the basis of the control group. Blood glucose, fasting insulin, 25-hydroxyvitamin D3 [25- (OH) D3] levels and pregnancy outcomes were compared and analyzed between the two groups. Results After treatment, the blood glucose level and fasting insulin of the observation group were lower than those of the control group (P＜0.05), and the serum 25- (OH) D3 level was higher than that of the control group (P＜0.05). The natural delivery rate of the observation group was higher than that of the control group, and the incidence of adverse pregnancy outcomes was lower than that of the control group (P＜0.05). Conclusion The combination therapy of Vit D and insulin detemir can effectively reduce blood glucose levels and fasting insulin levels in patients with GDM, increase serum 25- (OH) D3 levels.