ISSN 2097-5724 CN 61-1535/R 主管·主办:陕西省疾病预防控制中心
疾病预防与控制 Disease Prevention and Control 医学学术期刊 双月刊
2025-04-017 临床药物应用 2025, (04)

分析血塞通,硝酸甘油,多巴胺联合治疗慢性肺源性心脏病心力衰竭的临床价值

罗甸县中医医院

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摘要

目的 研究血塞通、硝酸甘油、多巴胺联合治疗慢性肺源性心脏病心力衰竭的应用效果。方法 选取2022 年 12 月至 2024 年 12 月在贵州省黔南布依族苗族自治州罗甸县中医医院心血管内科接受治疗的 80 例慢性肺源性心脏病心力衰竭患者,采取随机数字表法分组,各 40 例,对照组患者接受常规治疗,研究组患者在常规治疗的基础上使用血塞通、硝酸甘油、多巴胺联合治疗,对比两组患者咳嗽、咳痰、气短气促临床症状消失时间,左心室射血分数、6 min 步行试验和 N 末端 B 型钠尿肽原(NT-proBNP)心功能指标,用力肺活量(FVC)、第一秒用力呼气量(FEV1)和 FEV1/FVC 肺功能指标。结果 研究组患者咳嗽、咳痰、气短气促临床症状改善时间短于对照组(P<0.05)。治疗 2 周时,两组患者左心室射血分数和 6 min 步行试验均有提升(P<0.05),研究组优于对照组(P<0.05);两组患者 NT-proBNP 均有下降(P<0.05),研究组低于对照组(P<0.05)。治疗 2 周时,两组患者 FVC、FEV1、FEV1/FVC 肺功能指标均有提升(P<0.05),研究组高于对照组(P<0.05)。结论 血塞通、硝酸甘油、多巴胺联合治疗可有效缩短慢性肺源性心脏病心力衰竭的临床症状改善时间,对肺功能和心功能的改善程度优于常规治疗。

Abstract

Objective To investigate the application effect of combined treatment with Xuesaitong, nitroglycerin, and dopamine for chronic pulmonary heart disease with heart failure. Methods A total of 80 patients with chronic pulmonary heart failure who were treated in the Department of Cardiology of Luodian County Traditional Chinese Medicine Hospital in Qiannan Buyi and Miao Autonomous Prefecture, Guizhou Province from December 2022 to December 2024 were enrolled. The patients were divided into two groups using the random number table method, with 40 cases in each group. The control group received conventional treatment, while the study group received combined treatment with Xuesaitong, nitroglycerin, and dopamine on the basis of conventional treatment. The disappearance time of clinical symptoms such as cough, sputum, and dyspnea was compared between the two groups, as well as the cardiac function indicators of left ventricular ejection fraction, 6-minute walking test, and N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the pulmonary function indicators of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC. Results The improvement time of clinical symptoms such as cough, sputum, and shortness of breath in the study group was shorter than that in the control group (P<0.05). After 2 weeks of treatment, left ventricular ejection fraction and 6-minute walking test results increased significantly in both groups (P<0.05), and the study group achieved better outcomes than the control group (P <0.05) ; The NT-proBNP of both groups decreased (P<0.05), and the study group was lower than the control group (P<0.05). After 2 weeks of treatment, the FVC, FEV1, and FEV1/FVC of both groups were improved (P<0.05), and the study group was higher than the control group (P<0.05). Conclusion Combined treatment with Xuesaitong, nitroglycerin, and dopamine can effectively shorten the improvement time of clinical symptoms of chronic pulmonary heart disease with heart

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[1]安祖芳.分析血塞通,硝酸甘油,多巴胺联合治疗慢性肺源性心脏病心力衰竭的临床价值[J],2025,01(04):.