研究海东地区糖化血红蛋白变异体诊断意义

Objective To investigate the value of fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), and hemoglobin A1c variants in the diagnosis of diabetes, and to analyze the characteristics and clinical significance of abnormal HbA1c chromatographic patterns. Methods A prospective observational study was conducted, enrolling 210 suspected diabetic patients. FBG, HbA1c, and HbA1c variant patterns were detected, with clinical diagnosis as the gold standard. The sensitivity, specificity, accuracy, and Kappa value of each test were evaluated, and ROC curves were drawn to analyze the correlation between variants and clinical variables. Results The sensitivity, specificity and accuracy of the combined detection of the three factors were 95.6%, 91.5% and 93.2% respectively, with an AUC of 0.961. The abnormal detection rate of HbA1c profiles was 15.2%. The variants were significantly correlated with age, body mass index(BMI) and duration of diabetes. Conclusion HbA1c variants significantly impact the accuracy of diabetes diagnosis, with chromatographic identification having independent diagnostic value. The combined detection strategy can significantly improve screening efficiency, especially in the recognition of hemoglobin variants. It is recommended to incorporate variant identification mechanisms into clinical testing to enhance early diagnosis and management of diabetes.