扇形束计算机断层扫描在肺癌容积旋转调强计划精准治疗中的临床应用研究
常州市肿瘤医院
目的 探讨扇形束计算机断层扫描(FBCT)在肺癌容积旋转调强(VMAT)计划精准治疗中的临床应用效果。方法 纳入2023年10月至2025年9月在本院收治的30例患者为研究对象,其均接受VMAT放疗治疗。根据计算机断层扫描(CT)扫描定位方式不同,分成两组,即观察组和对照组,每组各15例,前者在FBCT引导下开展治疗,后者在锥形束计算机断层扫描(CBCT)引导下开展治疗,对比两组靶区定位误差、计划靶区(PTV)剂量覆盖参数、适形指数(CI)、均匀性指数(HI)及时间效率。结果 观察组在X、Y、Z三个方向的定位误差均显著低于对照组(P<0.05);观察组的D95%、D98%、V100%均显著高于对照组(P<0.05);观察组CI高于对照组,HI低于对照组(P<0.05);观察组图像扫描时长长于对照组,但总摆位时长及图像配准时长短于对照组(P<0.05)。结论 FBCT引导可显著提高肺癌VMAT计划的靶区定位精度和剂量覆盖准确性,为临床开展精准放疗方案提供重要的技术保障。
Objective To explore the clinical application effect of fan-beam CT(FBCT) in the precise treatment of volume intensity modulated(VMAT) plan for lung cancer. Methods From October 2023 to September 2025, 30 patients in our hospital were selected as the research subjects, all of whom received VMAT. According to the CT scanning positioning methods, they were divided into two groups, namely, the observation group and the control group, with 15 cases in each group. The former was treated under the guidance of FBCT and the latter was treated under the guidance of cone-beam CT(CBCT). The target positioning error, dose coverage parameters of planned target area(PTV), conformity index(CI), uniformity index(HI) and time efficiency of the two groups were compared. Results The positioning errors of the observation group in X, Y and Z directions were significantly lower than those of the control group(P<0.05). The D95%, D98% and V100% in the observation group were significantly higher than those in the control group(P<0.05). CI in observation group was Higher than that in control group, and HI was lower than that in control group(P<0.05). The image scanning time in the observation group was longer than that in the control group, but the total setting time and image registration time were shorter than those in the control group(P<0.05). Conclusion FBCT guidance can significantly improve the target location accuracy and dose coverage accuracy of VMAT plan for lung cancer, and provide important technical support for clinical precision radiotherapy.
引用本文
按标准格式复制,或导出到文献管理软件参考文献
共 13 条- [1]O’Brien RT,Dillon O,Lau B,et al. The first-in-human implementation of adaptive 4D cone beam CT for lung cancer radiotherapy:4DCBCT in less time with less dose[J]. Radiotherapy and Oncology,2021,161:29-34.
- [2]张皓嘉,张毅,金海洁,等.中央型肺癌容积旋转调强放疗计划中减少肺低剂量体积的研究[J].中国医疗器械杂志,2025,49(2):181-185.
- [3]雷亚楠,侯鹏,徐晓捷,等.非小细胞肺癌容积旋转调强患者并发放射性肺炎的影响因素[J].山西卫生健康职业学院学报,2022,32(4):45-47.
- [4]Guberina N,Pöttgen C,Santiago A,et al. Machinelearning-based prediction of the effectiveness of the delivered dose by exhale-gated radiotherapy for locally advanced lung cancer:The additional value of geometric over dosimetric parameters alone[J]. Frontiers in Oncology,2022,12(1):870432.
- [5]Duan J,Pogue JA,Boggs DH,et al. Enhancing precision in radiation therapy for locally advanced lung cancer:A case study of cone-beam computed tomography(CBCT)-based online adaptive techniques and the promise of HyperSight™iterative CBCT[J].Cureus,2024,16(8):e66943.
- [6]李小军,张雁山,任益民,等. Ⅲ期非小细胞肺癌碳离子放疗与光子容积旋转调强放疗的剂量学对比研究[J].现代肿瘤医学,2023,31(2):337-342.
- [7]于金明,袁双虎.肺癌精准放疗的进展与挑战[J].中华放射肿瘤学杂志,2021,30(1):1-5.
- [8]朱广迎,石安辉,李丹,等.早期非小细胞肺癌立体定向放疗中国专家共识(2022版)[J].中华放射肿瘤学杂志,2022,31(11):961-972.
- [9]胡逸民,张红志,戴建荣,等.肿瘤放射物理学(第2版)[M].北京:中国协和医科大学出版社,2021:256-278.
- [10]李晔雄,金晶,刘跃平,等.容积旋转调强技术在胸部肿瘤放疗中的应用进展[J].中华放射肿瘤学杂志,2023,32(2):103-108.
- [11]陈明,王军,袁智勇,等.局部晚期非小细胞肺癌自适应放疗中国专家共识[J].中华放射肿瘤学杂志,2024,33(1):1-10.
- [12]傅小龙,赵快乐,蒋国梁,等.图像引导放疗技术在肺癌精确放疗中的临床应用[J].中国癌症杂志,2022,32(5):385-392.
- [13]王绿化,惠周光,毕楠,等.不可切除局部晚期非小细胞肺癌放化疗共识(2021版)[J].中华放射肿瘤学杂志,2021,30(6):541-549.
| 文章编号 | 2026-06-043(期号内编号) |
|---|---|
| 栏目 | 检验与方法 |
| 作者 | 吴文斌 |
| 作者单位 | 常州市肿瘤医院 |
| 中图分类号 | R734.2 |
| 卷期页码 | 2026, 2(06): 169-172 |
| 发布时间 | 2026-09-15 |
| 出版时间 | 2026-09-15 |
| 引用信息 | [1]吴文斌.扇形束计算机断层扫描在肺癌容积旋转调强计划精准治疗中的临床应用研究[J].疾病预防与控制,2026,2(06):169-172. |
| 全文地址 | 在知网查看该文(kns.cnki.net) |
| 数据抓取时间 | 2026-10-15T03:31:32 |