宫腔镜下子宫内膜息肉切除术联合屈螺酮炔雌醇片治疗子宫内膜息肉的效果分析

Objective To explore the clinical efficacy of combined use of drospirenone and ethinylestradiol tablets with endometrial polyp resection under hysteroscopy in the treatment of endometrial polyps, to provide evidence-based basis for the comprehensive management strategy after endometrial polyp surgery, and to offer certain references for the optimization of relevant clinical pathways and the improvement of subsequent diagnosis and treatment norms. Methods Using a prospective controlled study design, 120 patients aged 18～45 years who underwent hysteroscopic endometrial polypectomy at the gynecology department of Jincheng Maternal and Child Health Hospital between February 2018 and July 2025 were enrolled. The patients were divided into an experimental group(n=60) and a control group(n=60) based on the random number table method. The control group underwent only routine follow-up after hysteroscopic polypectomy, while the experimental group received oral drospirenone and ethinylestradiol tablets starting on the first day of their first postoperative menstrual cycle, for a total of 3 consecutive cycles. The two groups were compared in terms of postoperative menstrual improvement, changes in endometrial thickness, recurrence rates at 12 months, and incidence of adverse reactions. Results Both menstrual length and Pictorial Blood Loss Assessment Chart(PBAC) score in the experimental group were better than those in the control group, with statistically significant differences(P<0.05). At 3-month and 6-month postoperative follow-up, the endometrial thickness in the experimental group respectively, superior to that in the control group with significant differences(P<0.05). Additionally, the postoperative recurrence rate in the experimental group was 1.67%, markedly lower than that in the control group(11.67%)(P<0.05). No statistically significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Hysteroscopic endometrial polypectomy combined with drospirenone and ethinylestradiol tablets can help improve the postoperative endocrine environment, promote endometrial repair, and significantly reduce the risk of endometrial polyp recurrence, with good safety.