股四头肌等长收缩联合富血小板血浆治疗早中期膝关节炎患者的临床疗效观察

Objective To observe the clinical efficacy of isometric contraction of quadriceps muscles combined with platelet-rich plasma(PRP) joint cavity injection in the treatment of early and mid-stage knee osteoarthritis. Methods 40 patients with early and mid-stage knee osteoarthritis treated in the orthopedic outpatient department of Beijing Jishuitan Hospital Guizhou Hospital from October 2024 to June 2025 were selected as the research objects. They were divided into groups according to the random number table method. The control group only received intra-articular injection of PRP, while the observation group added isometric contraction training of the quadriceps femoris muscle on the basis of the control group. The visual analogue scale score(VAS), Lysholm knee joint score, Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC), isokinetic muscle peak torque and quadriceps femoris muscle thickness were compared between the two groups before and after the intervention, and the clinical effective rate was evaluated. Results After 12 weeks of intervention, the visual analog scale score and WOMAC index of the observation group were lower than those of the control group, the Lysholm score, knee extension peak torque, and quadriceps muscle thickness of the observation group were higher than those of the control group(P<0.05). The total effective rate of the observation group was higher than that of the control group(P<0.05). Conclusion Isometric contraction of quadriceps muscles combined with PRP injection can effectively relieve pain in patients with early and mid-stage knee osteoarthritis, improve knee joint function, enhance knee extension muscle strength, delay quadriceps muscle atrophy, and the therapeutic effect is better than that of simple PRP injection.