一例“难治性哮喘”的真相探寻与病因拆解

This paper presents the clinical case of a 26-year-old woman with persistent refractory asthma for 18 years. She has frequent coughing, sputum production and shortness of breath, and her condition has not improved with various asthma treatment methods. Based on the review of her medical history, she has accumulated pericardial fluid over a long period of time, has chronic sinusitis and nasal polyps, and shows a prolonged rise in peripheral eosinophils. Given the multi-system involvement, it was finally determined that the person had eosinophilic granulomatosis with polyangiitis(EGPA). Mepolizumab is an anti interleukin-5(IL-5) monoclonal antibody that can help reduce symptoms and improve lung function in the treatment of EGPA. However, given that the disease may worsen later, early detection and timely handling of patients with EGPA are still necessary.