注射用腺苷钴胺联合常规方案治疗腰椎间盘突出症的疗效观察

Objective To investigate the clinical efficacy and safety of adenosine cobalamin for injection combined with conventional regimen in the treatment of lumbar disc herniation(LDH) in a community health service center setting. Methods Eighty LDH patients who presented at our center between June 2024 and June 2025 were selected and randomly divided into a combination group(n=40) and a control group(n=40) using a random number table. The control group received conventional treatment, including bed rest, oral diclofenac sodium sustained-release tablets, and lumbar traction. The combination group received an additional daily intramuscular injection of 1 mg adenosine cobalamin for injection on top of the control group's regimen. The treatment course for both groups was 4 weeks. The Visual Analogue Scale(VAS) scores, the Oswestry Disability Index(ODI) scores, the lumbar range of motion, and the incidence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, the VAS scores were(2.95±0.71) points in the combination group and(4.08±0.92) points in the control group, while the ODI scores were(41.20±3.15) points and(46.95±3.28) points, respectively. The improvement in these indicators was significantly greater in the combination group than in the control group(P<0.05). The total effective rate of the combined group was higher than that of the control group(P<0.05). Improvements in lumbar flexion-extension, lateral bending, and rotational range of motion were also significantly greater in the combination group compared to the control group(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion In community health service centers, the use of adenosine cobalamin for injection combined with a conventional regimen for LDH treatment can more effectively alleviate pain, improve lumbar function and range of motion, enhance quality of life, and demonstrates good safety, making it worthy of promotion in primary care settings.