基于事故树模型的流行性出血热实验室获得性感染事件分析

Objective To analyze the causes of laboratory-acquired infections of epidemic hemorrhagic fever, so as to provide a basis for the preventive strategies and measures against such laboratory-acquired infection incidents. Methods By adopting the fault tree analysis(FTA) method, a laboratory-acquired epidemic hemorrhagic fever infection incident involving 10 individuals that occurred in the Department of Traditional Chinese Medicine of a medical college in 2006 was taken as the top event, and a fault tree model was established to trace the root causes. Results Seventeen potential pathways of laboratory-acquired epidemic hemorrhagic fever infections were identified and six preventive measures were proposed. Among them, seven pathways were the most critical influencing factors for the top event, including failure of laboratory personnel to complete vaccination, non-compliant procurement of laboratory mice, secondary infection of laboratory mice during breeding, failure to wear personal protective equipment(PPE) in accordance with regulations, use of defective PPE that does not meet biosafety standards, improper PPE wearing practices and inappropriate PPE selection. Conclusion The FTA method demonstrated a favorable application effect in the preventive analysis of laboratory-acquired epidemic hemorrhagic fever infections, which can provide a theoretical basis for laboratories to formulate targeted prevention and control strategies and specific measures accurately.