艾司氯胺酮复合瑞马唑仑在宫腔镜术中的应用

Objective To explore the application effect of esketamine combined with remimazolam in hysteroscopic surgery. Methods A total of 86 patients undergoing hysteroscopic surgery from January 2024 to December 2024 in our hospital were selected, and randomly divided into both groups. The control group(n=43) received propofol and dexmedetomidine anesthesia, the study group(n=43) received esketamine and remimazolam anesthesia. The anesthesia efficacy, quality of postoperative recovery, incidence of adverse reactions, preoperative and postoperative stress indicators, and vital signs at different time points were compared in both groups. Results The anesthesia efficacy rate of the study group was significantly higher than that of the control group(P<0.05). The postoperative respiratory recovery time, orientation recovery time, and eye-opening time in the study group were shorter than those in the control group(P<0.05). There were no statistically significant differences in the incidence of adverse reactions between the two groups(P>0.05). 1 day after operation, serum cortisol(Cor), plasma adrenaline(E), and plasma noradrenaline(NE) levels increased in both groups(P<0.05), but the levels in the study group were lower than those in the control group(P<0.05). At 3 minutes after anesthesia induction(T2) and during cervical dilation(T3), compared to the control group, heart rate(HR) and mean arterial pressure(MAP) levels in the study group were higher(P<0.05). Conclusion Esketamine and remimazolam anesthesia can improve the anesthesia efficacy rate and postoperative recovery quality in hysteroscopic surgery, with minimal impact on vital signs and stress indicators, demonstrating high safety.