瑞马唑仑与丙泊酚在老年髋部骨折全身麻醉中的应用比较

Objective To compare the efficacy of remimazolam and propofol in elderly patients undergoing general anesthesia for hip fracture surgery. Methods A total of 102 elderly patients with hip fractures from January 2024 to June 2025 who underwent general anesthesia in our hospital were retrospectively selected. Based on the anesthetic agents used, 51 patients in the propofol group were administered propofol, while 51 patients in the remimazolam group received remimazolam. Vital signs and respiratory suppression indicators at different time points were compared in both groups, and the incidence of adverse reactions, postoperative consciousness recovery time, and postoperative delirium rates were recorded. Results In heart rate(HR) and mean arterial pressure(MAP) before anesthesia(T0), both groups were no statistically significant differences(P>0.05). In comparison of the propofol group, the HR and MAP levels in the remimazolam group were higher at 1 minute after anesthesia(T1), 1 minute after intubation(T2), and 10 minutes after intubation(T3)(P<0.05). In respiratory rate(RR) and oxygen saturation(SpO2) at T0, T2, and T3, both groups were no statistically significant differences(P>0.05). The SpO2 difference at T1 was no statistically significant(P>0.05), but in comparison of the propofol group, the RR level in the remimazolam group was higher at T1(P<0.05). In the incidence of adverse reactions, both groups were no statistically significant differences(P>0.05). In the postoperative recovery times for respiration, orientation, and eye opening, in comparison of the propofol group, the remimazolam group was shorter(P<0.05). In postoperative delirium rates or delirium scores, both groups were no statistically significant differences(P>0.05). Conclusion Both remimazolam and propofol demonstrate high safety in elderly patients undergoing general anesthesia for hip fracture surgery, with a low risk of postoperative delirium. However, remimazolam better maintains hemodynamic stability, reduces respiratory depression, and shortens postoperative consciousness recovery time.