超声联合亚甲蓝定位不可触及乳房结节在开放手术中的应用

Objective To evaluate the clinical value of ultrasound combined with methylene blue localization in open surgery for non-palpable breast nodules. Methods A total of 200 patients with clinically non-palpable breast nodules classified as Breast Imaging Reporting and Data System(BIRADS) category 3 or higher were randomly assigned to an experimental group(n=100) and a control group(n=100). The experimental group first used color Doppler ultrasound to locate the nodule preoperatively and, under ultrasound guidance, injected an appropriate amount of methylene blue into the nodule, followed by open surgical treatment. The control group used only ultrasound for skin surface localization of the nodule, followed by open surgical treatment. The accuracy of first-attempt success rate of lesion resection, max distance from the target lesion to the tissue margin(mm) and weight of the excised tissue(g), operation time, and postoperative complications were compared. Results The first-attempt success rate of lesion resection were 96.00% in the experimental group and 86.00% in the control group. The success rate of the experimental group was higher, and the difference was statistically significant(P<0.05). The excised tissue weight was(14.74±3.39)g in the experimental group which was less than that in the control group(28.04±4.69)g(P<0.05). The maximum distance between the target lesion and the tissue margin was(5.14±1.79) mm in the experimental group which was less than that in the control group(7.77±1.86) mm, and the difference was statistically significant(P<0.05). The operation time of the experimental group(25.00±1.90) min was shorter than of the control group(33.00±3.20) min(P<0.05). There was no statistically significant difference in the incidence of postoperative complications between the two groups of patients(P>0.05). Conclusion Ultrasound combined with methylene blue localization improves the accuracy of resection, reduces the excision of normal tissue, shortens operation time, and does not increase surgical risk, demonstrating significant clinical applicability.