瑞马唑仑在高血压脑出血手术麻醉中的应用效果

Objective To explore the application effect of remimazolam in anesthesia for hypertensive intracerebral hemorrhage(HICH) surgery. Methods A total of 86 patients undergoing HICH surgery from August 2023 to January 2025 who were admitted in our hospital were selected, and randomly divided into the control group(n=43, anesthetized with propofol) and the study group(n=43, anesthetized with remimazolam). The anesthesia related indicators, hemodynamic levels at different time points, bispectral index(BIS), neurological function, and adverse reactions in both groups were compared. Results In comparison of the control group, the induction time of anesthesia in the study group was shorter(P<0.05). In comparison of the control group, the heart rate(HR) and mean arterial pressure(MAP) of the study group were higher immediately after tracheal intubation(T1), during hematoma clearance(T2), and at the end of surgery(T3)(P<0.05), and the hemodynamic level of the study group was more stable than that of the control group. In comparison of the control group, the BIS of the study group was lower(P<0.05). In comparison of the control group, the National Institutes of Health Stroke Scale(NIHSS) scores of the study group were lower at 1 and 6 months after surgery(P<0.05). In the incidence of adverse reactions, in comparison of the control group, the study group was lower(P<0.05). Conclusion The use of remimazolam in HICH surgery anesthesia can shorten the anesthesia induction time, alleviate hemodynamic fluctuations, maintain the sedative effect, improve neurological function deficits and reduse the incidence of adverse reactions.