四维 CT 在肺癌立体定向放射治疗中的应用效果分析

Abstract: Objective To analyze the application effectiveness of four-dimensional computed tomography (4D-CT) and conventional three-dimensional computed tomography (3D-CT) in stereotactic radiotherapy (SBRT) for lung cancer, providing reference for optimizing clinical precision radiotherapy plans. Methods A total of 78 patients who received SBRT for lung cancer at our hospital between January 2022 and June 2025 were selected and randomly divided into 4DCT group (39 cases) and conventional group (39 cases). The conventional group used Toshiba Aquilion PRIME 3D-CT for radiotherapy positioning and plan formulation, while the 4D-CT group employed United Imaging uCT-610sim 4DCT for positioning and plan formulation. Both groups completed SBRT treatment according to standard protocols. Post-treatment, precision metrics, treatment efficacy, and complication rates were compared using United Imaging planning system. Results The 4D-CT group demonstrated superior tumor target coverage (CI), conformity index (HI), and normal tissue radiation dose compared to the conventional group. The total effective rate of treatment was higher than that of the conventional group, while the overall complication rate was lower, with statistically significant differences (P＜0.05). Conclusion The application of United Imaging uCT-610sim 4D-CT for positioning and treatment planning in stereotactic radiotherapy for lung cancer demonstrates significantly improved precision compared to Toshiba’s Aquilion PRIME 3D-CT. This advancement enhances therapeutic outcomes while reducing complication risks, making it clinically valuable