磁共振氢质子波谱、脑脊液乳酸水平对患儿癫痫发病机制的研究

Abstract: Objective To explore the correlation between magnetic resonance hydrogen proton spectroscopy detection ( 1 H-MRS) and cerebrospinal fluid lactate level determination with the pathogenesis of epilepsy in children. Methods Eighteen children with epileptic seizures admitted to our hospital from January 2023 to December 2024 were selected as the observation group. All of them were diagnosed for the first time and had epileptic seizures within 24 hours before admission. Eighteen patients with simple febrile convulsions and gastroenteritis with benign convulsions who were admitted to the hospital for treatment during the same period were selected as the control group. The weight, incidence of developmental delay and the levels of cerebrospinal fluid lactate, blood lactic acid, the results of 1 H-MRS, the results of Logistic multivariate regression, and the correlation were observed between the two groups of children patients. Results The body weight of the observation group was lower than that of the control group, and the rate of developmental delay was higher than that of the control group. The statistical results showed significant differences (P＜0.05). The levels of cerebrospinal fluid lactate and blood lactic acid in the observation group were higher than those in the control group, and the statistical results showed significant difterences (P＜0.05). The N-acetylaspartate/ creatine (NAA/Cr) in the observation group was lower than that in the control group, while the choline/creatine (Cho/Cr) and myoinositol/creatine (MI/Cr) were higher than those in the control group. The statistical results showed significant differences (P＜0.05). Decreased NAA/Cr, increased Cho/Cr, increased MI/Cr, and elevated cerebrospinal fluid lactate and blood lactate were all associated with the onset of epilepsy (P＜0.05). Conclusion 1 H-MRS and cerebrospinal fluid lactate level determination have a certain correlation with the onset of epilepsy in children. Clinically, these tests can assist in clinical diagnosis and treatment.