脾氨肽冻干粉联合丙酸氟替卡松治疗变应性鼻炎的效果

Abstract: Objective To explore the treatment of allergic rhinitis with spleen aminopeptide lyophilized powder combined with fluticasone propionate nasal spray and its effect on airway stress response in patients. Methods Eighty patients with allergic rhinitis who were treated at Xi’an Baoshihua Changqing Hospital from January 2022 to January 2025 were selected as the research subjects and divided into two groups according to the random number table method. The control group was treated with fluticasone propionate nasal spray (a total of 40 cases), while the observation group was supplemented with spleen aminopeptide lyophilized powder on the basis of the control group (a total of 40 cases). The immunoglobulin E (IgE), inflammatory indicators, airway stress response, therapeutic effect and occurrence of adverse reactions were compared between the two groups. Results There was no significantly difference in total IgE, inflammatory indicators, and airway stress response between the two groups before treatment (P＞0.05). After treatment, the interferon-γ (IFN-γ) in the observation group was higher than that in the control group. The total IgE, eosinophils (EOS), interleukin-4 (IL-4) and Total Nasal Symptom Score (TNSS) were lower than those of the control group (P＜0.05). There was no difference in the total incidence of epistaxis, nasal dryness and headache between the two groups (P＞0.05). Conclusion The treatment of allergic rhinitis patients with spleen aminopeptide lyophilized powder combined with fluticasone propionate nasal spray can reduce the total IgE of patients, alleviate inflammatory responses, and relieve airway stress responses. It has definite clinical efficacy and high safety.