开塞露联合布拉氏酵母菌治疗急性胰腺炎肠麻痹的效果

Abstract: Objective To investigate the effect of glycerin enema combined with saccharomyces boulardii on intestinal paralysis in acute pancreatitis (AP). Methods A total of 120 AP patients with intestinal paralysis admitted to our hospital from November 2023 to May 2025 were randomly divided into the control group and the observation group, with 60 cases in each group. Both groups received conventional treatment. The control group received glycerin enema, while the observation group received sequential enema with glycerin enema combined with saccharomyces boulardii. Clinical efficacy, levels of c-reactive protein (CRP), white blood cells (WBC), procalcitonin (PCT), serum amylase (AMY), motilin (MTL), gastrin (GAS), vasoactive intestinal peptide (VIP) and gastrointestinal function indicators were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group. After treatment, the levels of CRP, WBC, PCT, and AMY were significantly lower, while levels of MTL and GAS were significant higher. VIP levels were significantly lower. Additionally, the recovery time of bowel sounds, time to first flatus, and time to first defecation were significantly shorter in the observation group than in the control group (P＜0.05). Conclusion Compared with glycerin enema alone, sequential enema with glycerin enema combined with saccharomyces boulardii is more effective in controlling disease progression, promoting the recovery of gastrointestinal function, reducing AMY levels, and alleviating systemic inflammatory response in AP patients with intestinal paralysis. This approach can provide guidance for the clinical treatment of intestinal paralysis in AP.