脓毒症患者炎症因子水平与预后的相关性研究

Abstract: Objective To explore the correlation between levels of inflammatory factors and prognosis in patients with sepsis. Methods A total of 80 patients with sepsis treated in Zhuhai Hospital of Guangdong Provincial People’s Hospital (Zhuhai Jinwan Cemtral Hospital) from January 2020 to December 2023 were selected as the research objects according to the inclusion and exclusion criteria. According to the survival situation, they were divided into survival group and death group as the research objects, with 40 cases in each group. The data were analyzed according to the previous tests of our group [venous blood was drawn to detect the expression levels of inflammatory factors in serum by flow cytometry and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score]. Finally, Pearson correlation analysis was used to analyze the correlation between the levels of related inflammatory factors and the prognosis. Results The serum interferon-γ (IFN-γ) expression level in the survival group was significantly higher than that in the death group, while the serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels and APACHE Ⅱ score in the survival group were significantly lower than those in the death group, and the differences were statistically significant (P＜0.05). At the same time, the expression levels of inflammatory factors were significantly correlated with the prognosis of patients (the r values of IFN-γ, TNF-α and IL-6 were -0.801, 0.700 and 0.728, respectively, P＜0.05). Conclusion The expression levels of inflammatory factors have a certain correlation with the prognosis of patients with sepsis, among which IFN-γ was significantly negatively correlated. There was a significant positive correlation between TNF-α and IL-6. This correlation can provide certain guiding significance for targeted therapy and prognosis stratification of sepsis.