右美托咪定对经皮冠状动脉介入治疗患者心脏功能改善的作用机制探讨

Abstract: Percutaneous coronary intervention (PCI) is an important means of revascularization for patients with coronary heart disease. However, surgical trauma, ischemia-reperfusion injury and perioperative stress responses may lead to myocardial dysfunction. Dexmedetomidine, as a highly selective α2-adrenergic receptor agonist, has demonstrated potential cardioprotective effects in the perioperative application of PCI. This article systematically explores the pathways through which dexmedetomidine improves cardiac function in PCI patients by reviewing its pharmacological properties and combining with the mechanisms of PCI surgery affecting cardiac function. These pathways include inhibiting excessive sympathetic activation, reducing myocardial ischemia-reperfusion injury, regulating inflammatory responses and oxidative stress and protecting myocardial cell structure and metabolism. Research has shown that dexmedetomidine can stabilize hemodynamics in PCI patients, reduce the release of myocardial injury markers and improve cardiac function indicators through multi-target and multi-link synergistic effects, providing new theoretical bases and clinical ideas for cardioprotection during the perioperative period of PCI.