加味左金丸治疗肝胃不和型反流性食管炎临床效果观察

Abstract: Objective To observe the clinical effect of Modified Zuojin Pill combined with Wubei Powder in the treatment of reflux esophagitis of Liver-Stomach Disharmony Type. Methods A total of 70 patients with reflux esophagitis due to disharmony between the Liver-Stomach Disharmony Type were selected for the study from January 2022 to July 2025. They were randomly grouped using a random number table, with 35 cases in each group. The control group was treated with omeprazole enteric-coated capsules, while the observation group, on the basis of the control group, was treated with Modified Zuojin Pill and Wubei Powder after diagnosis based on the clinical symptoms and signs of the patients. The study compared the Traditional Chinese Medicine (TCM) Syndrome Scores, tongue and pulse changes, clinical efficacy and adverse reactions of the two groups. Results Before treatment, there was no significant difference in the TCM Syndrome Scores between the two groups of patients with reflux esophagitis of Liver-Stomach Disharmony Type (P＞0.05). After 8 weeks of treatment, the TCM Syndrome Scores of patients with reflux esophagitis of Liver-Stomach Disharmony Type in both groups decreased significantly compared with those before treatment, and the decrease was more significant in the observation group (P＜0.05). Before treatment, the proportions of abnormal tongue images and pulse images in both groups were relatively high, and there was no significant difference between the groups (P＞0.05). After treatment, the proportion of abnormal tongue appearance and abnormal pulse appearance in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P＜0.05). Before treatment, there was no significant difference in the total scores of the reflux disease questionnaire, gastroesophageal reflux disease questionnaire and reflux symptom index between the two groups (P＞0.05). After treatment, the total scores of the above scales decreased significantly, and the total scores of the observation group was significantly lower than that of the control group (P＜0.05). Conclusion The treatment of reflux esophagitis of Liver-Stomach Disharmony Type with Modified Zuojin Pill and Wubei Powder has a significant effect. It can significantly increase the total clinical effective rate, reduce the TCM Syndrome Score of patients, improve the tongue appearance and pulse of patients, and has a lower incidence of adverse reactions.