生化检验联合凝血功能指标检测对肝病患者预后的评估价值

Objective To analyze the evaluation value of combined biochemical test and coagulation function index detection for the prognosis of patients with liver diseases, and to provide a direction for the subsequent formulation of prognosis improvement plans. Methods This study employed a retrospective analysis. We collected data from 87 patients diagnosed with liver diseases admitted to our hospital from January 2023 to June 2025, who were included in the case group. Simultaneously, 75 healthy individuals undergoing physical examinations were selected as the normal group. After a 12-month follow-up, the case group was further divided into a subgroup with good prognosis(57 cases) and a subgroup with poor prognosis(30 cases). All subjects underwent biochemical testing [alanine aminotransferase(ALT), aspartate aminotransferase(AST), serum albumin(ALB), total bilirubin(TBIL), cholinesterase(CHE), and γ-glutamyltranspeptidase(GGT)] and coagulation function indicators [prothrombin time(PT), activated partial thromboplastin time(APTT), international normalized ratio(INR), fibrinogen(FIB), and platelets(PLT)]. Differences in indicators between groups were compared, and multivariable Logistic regression analysis was used to identify independent risk factors for liver disease prognosis. Results Statistical comparison between groups revealed that, compared to the normal group, the ALT, AST, TBIL, GGT, PT, APTT, and INR indicators in the case group exhibited an abnormal upward trend, while the ALB, CHE, FIB, and PLT indicators showed a significant downward trend(P<0.05). The subgroup with poor prognosis had significantly higher levels of TBIL, GGT, PT, APTT, and INR, and significantly lower levels of ALB, CHE, FIB, and PLT compared to the subgroup with good prognosis(P<0.05). Multivariable Logistic regression analysis identified TBIL, ALB, CHE, INR, and FIB as independent risk factors for the prognosis of liver disease patients(P<0.05). Conclusion Patients with liver diseases exhibit significant biochemical metabolism and coagulation dysfunction. TBIL, ALB, CHE, INR, and FIB are independent risk factors for prognosis. Combined detection helps enhance the accuracy of prognostic evaluation, providing a reliable basis for clinical diagnosis, treatment, and early intervention of liver diseases.