心肌标志物联合凝血功能检测在急性胸痛患者早期诊断中的应用研究

Objective To explore the application effect of myocardial markers detection combined with coagulation function testing in the early diagnosis of acute chest pain patients. Methods The research period was from May 2024 to May 2026. 120 patients with acute chest pain admitted during this period were selected as the research subjects. Among them, 72 patients with cardiogenic chest pain were the experimental group, and 48 patients with non-cardiogenic chest pain were the control group. Both groups of patients underwent myocardial marker detection and coagulation function testing, and the test results were summarized. Results The levels of cardiac troponin I(cTnI), myoglobin(Myo), creatine kinase isoenzyme MB(CK-MB), and B-type natriuretic peptide(BNP) in the experimental group were significantly higher than those in the control group(P<0.05). The coagulation function index data showed that the levels of D-Dimer(D-D) and fibrinogen(FIB) in the experimental group were higher than those in the control group, and the levels of prothrombin time(PT) and activated partial thromboplastin time(APTT) were lower than those in the control group(P<0.05). The sensitivity, specificity and accuracy of myocardial markers combined with coagulation function test in the diagnosis of acute chest pain were higher than those of single myocardial markers or single coagulation function test(P<0.05). Conclusion Compared with non-cardiogenic chest pain patients, the levels of myocardial markers in cardiogenic chest pain patients increase, and the coagulation function is abnormal. Myocardial marker combined with coagulation function testing can accurately diagnose acute chest pain.