一株拮抗幽门螺杆菌的凝结魏茨曼氏菌的益生特性评价

Objective H. pylori infection is a major risk factor for various gastric diseases such as chronic gastritis and gastric ulcers, and traditional intervention methods have certain limitations. The application of probiotics to antagonize H. pylori has become a safe and efficient novel prevention and treatment strategy. This study aimed to screen a strain of Weizmannia coagulans with high anti-Helicobacter pylori activity and excellent probiotic properties, so as to provide bacterial resources and theoretical basis for the development of related functional probiotic products. Methods The agar diffusion assay was employed to screen W. coagulans YJY23-02 from infant feces for its ability to inhibit H. pylori growth. The strain's probiotic properties, including urease activity, cell adhesion, and co-aggregation ability, were evaluated. Results W. coagulans YJY23-02 exhibited an inhibition zone of 18.96±0.53 mm against H. pylori. It reduced H. pylori urease activity to 22.20%, decreased H. pylori adhesion to GES-1 cells by 84.84%, and demonstrated a co-aggregation rate of 68.59% with H. pylori within 24 hours. Conclusion The selected W. coagulans exhibited antagonistic effects against H. pylori and might serve as a potential candidate for developing functional products targeting H. pylori-related applications.