血清降钙素原、C反应蛋白及白细胞计数在儿童肺炎早期诊断中的价值

Objective To explore the application value of serum procalcitonin(PCT), C-reactive protein(CRP) and white blood cell count(WBC) in the early diagnosis of bacterial pneumonia in children. Methods 100 children with bacterial pneumonia who visited our hospital from January 2024 to December 2024 were selected as the observation group, and 100 children with non-bacterial respiratory tract infection who were admitted during the same period were selected as the control group. Both groups of children had their fasting venous blood collected within 24 hours after admission. Serum PCT levels were detected by electrochemiluminescence method, serum CRP levels were detected by immunoturbidimetry, and WBC counts were detected by an automatic blood cell analyzer. The differences in PCT, CRP and WBC levels between the two groups were compared, and the receiver operating characteristic(ROC) curve was drawn to analyze the diagnostic efficacy of each of the three indicators alone and in combination for bacterial pneumonia. Results The PCT, CRP and WBC levels in the observation group were higher than those in the control group(P<0.05). The PCT, CRP and WBC levels of severe children in the observation group were higher than those of mild children(P<0.05). ROC curve analysis showed that the AUC of PCT for diagnosing bacterial pneumonia was 0.93, which was greater than the AUC of CRP for 0.89 and the AUC of WBC for 0.84. The AUC of the combined detection of the three indicators was 0.97, which was higher than that of any single indicator detection. Conclusion Serum PCT, CRP and WBC have certain values in the early diagnosis of bacterial pneumonia in children. Among them, PCT has the best diagnostic efficacy. The combined detection can significantly improve the diagnostic accuracy and has important reference value for the early identification of bacterial pneumonia, assessment of the severity of the disease and guidance of clinical antibacterial treatment.