中性粒细胞/淋巴细胞比值、高敏C反应蛋白联合白细胞介素-6对克罗恩病活动期的诊断价值

Objective To explore the diagnostic value of combined detection of neutrophil-to-lymphocyte ratio(NLR), serum high-sensitivity C-reactive protein(hs-CRP) and interleukin-6(IL-6) in active Crohn's disease(CD), so as to provide laboratory evidence for rapid clinical assessment of CD activity. Methods A case-control study was conducted. A total of 130 patients diagnosed with CD in Foshan Fosun Chancheng Hospital from September 2022 to April 2025 were enrolled. According to Crohn's Disease Activity Index(CDAI) scores, they were divided into the active group(n=65, CDAI>150) and the inactive group(n=65, CDAI≤150). Fasting venous blood samples were collected to detect the levels of NLR, hs-CRP and IL-6. Non-parametric tests were used to compare differences between the two groups. Receiver operating characteristic(ROC) curve was applied to analyze the diagnostic efficacy of single index and combined three-index detection for active CD, and the optimal cut-off value, sensitivity, specificity and other diagnostic parameters were calculated. Results The levels of all indexes in the active group were significantly higher than those in the inactive group(Z=-5.39,-7.52,-7.67, P<0.05). ROC curve analysis showed that IL-6 had the best diagnostic efficiency among single indexes, with an area under the curve(AUC) of 0.890(95%CI: 0.837～0.943), a sensitivity of 75.38% and a specificity of 84.62%. The AUC of combined threeindex detection was 0.910(95%CI: 0.863～0.958), which was significantly higher than that of each single index. Serial detection yielded a specificity of 96.92%. Conclusion Combined detection of NLR, hs-CRP and IL-6 can significantly improve the diagnostic accuracy of active CD. Serial detection is suitable for confirmed diagnosis of active CD, and parallel detection applies to clinical screening. It provides reliable basis for dynamic monitoring of CD activity and clinical decision-making, with high clinical popularization value.