血清人附睾分泌蛋白4及肿瘤标志物与卵巢型子宫内膜异位症病情程度的相关性

Objective To observe the correlation between serum human epididymis secretory protein 4(HE4) and tumor markers and the severity of ovarian endometriosis(OMA).Methods A retrospective analysis was conducted on the medical records of 125 patients with OMA diagnosed and treated by pathological examination in our hospital from January 2022 to December 2024.General information,serum HE4 levels and tumor marker levels before treatment,were collected from all patients.The patients were divided into three groups according to disease staging:mild,moderate,and severe.The general information,serum HE4 levels,and serum tumor marker levels of the three groups were compared.Multivariate logistic analysis was used to investigate the relationship between serum HE4,CA125,CA199 levels and the severity of OMA patients.Spearman correlation analysis was used to investigate the relationship between the severity of OMA patients and their serum HE4 and tumor marker levels.Results There was no statistically significant difference in the general data among the three groups(P>0.05).There was no significant difference in the levels of serum alpha fetoprotein(AFP) and carcinoembryonic antigen(CEA) among the three groups of patients(P>0.05).There were significant differences in the levels of serum HE4,carbohydrate protein(CA125),and CA199 among the three groups of patients(P<0.05).The levels of serum HE4,CA125,and CA199 gradually increased with the severity of the disease(P<0.05).Multivariate Logistic regression analysis showed that serum HE4,CA125,and CA199 levels were risk factors for more severe disease in OMA patients(P<0.05).Spearman correlation analysis found that the serum levels of HE4,CA125,and CA199 in OMA patients were positively correlated with the severity of their condition(P<0.05).Conclusion The levels of serum HE4,CA125,and CA199 are correlated with the severity of OMA patients and have clinical detection value.