宫颈病变合并人乳头瘤病毒感染患者肿瘤标志物等影响因素分析

Objective To analyze the changes and influencing factors of tumor markers, T helper 1(Th1) cytokines and T helper 2(Th2) cytokines in patients with cervical lesionss complicated with human papillomavirus(HPV) infection. Methods A total of 150 patients with cervical lesionss admitted to the Affiliated Hospital of Shandong Second Medical University from June 2022 to December 2023 were selected and divided into highrisk group(n=79), low-risk group(n=32), mixed group(n=21), and non-combined group(n=18) according to the HPV infection status. Tumor markers and Th1 cytokines and Th2 cytokines were compared among the four groups. Logistic regression was used to analyze the influencing factors of cervical lesionss combined with HPV. Results The levels of SCCA, CEA, CA125 and IL-4 in the high-risk group and the mixed group were higher than those in the low-risk group and the non-combined group(P<0.05), while the levels of IL-12 and IFN-γ in the high-risk group and the mixed group were lower than those in the low-risk group and the non-combined group(P<0.05). The four groups of CA199 and IL-6 were statistically compared, and there was no difference(P>0.05). Logistic regression analysis revealed that the number of miscarriages [OR(95% CI): 9.826(1.003～10.286)], SCCA [OR(95% CI): 4.029(1.247～19.805)], CA125 [OR(95% CI): 3.846(1.049～1.848)], and IL12 [OR(95% CI): 0.986(3.549～9.870)] were the influencing factors for cervical lesionss combined with HPV infection(P<0.05). Conclusion Patients with cervical lesionss combined with HPV infection have high levels of SCCA, CEA, CA125, and IL-4, while low levels of IL-12 and IFN-γ. The risk factors are frequent miscarriages, low IL-12, and high levels of SCCA and CA125. Clinically, targeted intervention should be given as early as possible based on the above risk factors to minimize the HPV infection rate to the greatest extent.