盐酸戊乙奎醚注射液与阿托品治疗急性有机磷中毒患者疗效比较

Objective To evaluate the therapeutic effect of penehyclidine hydrochloride injection combined with atropine in the treatment of patients with acute organophosphorus poisoning(AOPP).Methods A total of 50 patients with AOPP admitted to the intensive care unit of our hospital from January 2022 to June 2025 were enrolled.The grouping method was chosen as the random number table method.There were two groups,each consisting of 25 cases.The control group received basic emergency drug administration and anticholinergic treatment with atropine,the experimental group received combined emergency treatment with penehyclidine hydrochloride injection and atropine.The rehabilitation indicators,myocardial enzyme profiles,serum inflammatory factors,complications and other indicators were collected and compared between the two groups.Results After the combined treatment in the experimental group,the clinical symptoms of AOPP patients disappeared,the activity of cholinesterase recovered,and the duration of mechanical ventilation and hospital stay were significantly shortened.Compared with the control group,the dosage and frequency of atropine used were also lower(P<0.05).After treatment in the experimental group,the measured values of blood oxygen partial pressure(PaO2) and gastric pH in patients were higher,and the incidence of complications was lower than that in the control group(P<0.05),after treatment,the levels of four typical myocardial enzyme spectrum indicators in the experimental group showed a downward trend,and compared with the control group(P<0.05).After treatment in the experimental group,compared with the control group,the levels of serum inflammatory indicators decreased(P<0.05).Conclusion The combined treatment regimen of penehyclidine hydrochloride injection+atropine is used in the treatment of acute organophosphorus poisoning(AOPP).It can quickly correct the patient's muscarinic and nicotinic symptoms,alleviate myocardial injury,alleviate the damage to the patient's myocardium,and accelerate the clearance of inflammatory substances in the body,thereby reducing the risk of complications.