25-羟基维生素D在育龄妇女自身免疫性甲状腺疾病中的应用研究

Objective To explore the significance and application value of 25-hydroxyvitamin D [25(OH)D3] in autoimmune thyroid diseases(AITDs) in women of childbearing age, and to provide laboratory evidence for the prevention and early intervention of AITDs in women of childbearing age. Methods Women of childbearing age aged 21～40 in this region were selected as the research subjects. The collection period was from January 2024 to June 2025. Among them, the observation group consisted of 105 patients with AITDs and were grouped according to the disease types. The control group consisted of 50 cases, including patients with hyperthyroidism, hypothyroidism and healthy women of childbearing age. The levels of 25(OH)D3 in the serum of all research subjects were determined by using the New Industry X8 fully automatic chemiluminescence detector. The thyroid-related antibodies and functional indicators in the serum of each group of subjects were detected. Specifically, it includes anti-thyroid peroxidase antibody(TPOAb), anti-thyroglobulin antibody(TGAb), thyroid stimulating hormone(TSH), free triiodothyronine(FT3), and free thyroxine(FT4). On this basis, the differences in serum 25(OH)D3 levels among different groups were compared, and the correlation between 25(OH)D3 levels and the above-mentioned thyroid antibodies was further analyzed. Results The serum 25(OH)D3 concentration in the observation group was lower than that in the control group, while the levels of thyroidrelated indicators(including TPOAb, TGAb, FT3, FT4 and TSH) were higher than those in the control group(P<0.05). The serum 25(OH)D3 levels of patients with different types of AITDs in the observation group were different, and there was a certain correlation between the 25(OH)D3 level and thyroid-related antibodies(P<0.05). Conclusion There are abnormal changes in the level of 25(OH)D3 in women of childbearing age with AITDs, and it is correlated with thyroid-related antibodies. It can be used as a reference indicator for the prevention and early intervention of AITDs in women of childbearing age.