孕晚期女性血浆D-二聚体参考区间建立及临床应用价值

Objective To establish plasma D-dimer reference intervals for women in late pregnancy and explore its clinical application value. Methods A retrospective analysis was conducted on plasma D-dimer data from 2,418 healthy women with singleton pregnancies in late pregnancy who underwent prenatal examination at Civil Aviation General Hospital from January 2022 to January 2025. They were divided into preterm and full-term groups, and further subdivided by age into<35 years and ≥35 years subgroups. 358 healthy non-pregnant women were selected as the control group. Spearman rank correlation was used to analyze the relationship between gestational age and D-dimer. The 95th percentile was used as the upper limit of the reference interval and 30 samples were collected for verification. Results D-dimer levels in late pregnancy were positively correlated with gestational age(r=0.227, P<0.05). Reference intervals were established: preterm ≤0.9 mg/L DDU, full-term(<35 years) ≤0.9385 mg/L DDU, full-term(≥35 years) ≤1.0260 mg/L DDU, all verified successfully. Conclusion The reference intervals for D-dimer in late pregnancy established in this study can provide important basis for clinical diagnosis of venous thromboembolism during pregnancy and reduce false positive misdiagnosis.