干燥综合征并发血小板减少患者血清Th17/Treg及免疫球蛋白检测结果分析

Objective To investigate the alterations of serum T-helper 17(Th17)/regulatory T(Treg) cells and immunoglobulins(Ig) in patients with Sjögren's syndrome(SS) complicated with immune thrombocytopenia(ITP). Methods Clinical data of 142 SS patients admitted to our hospital from April 2023 to April 2025 were retrospectively analyzed and assigned to the SS group, 30 age-matched healthy individuals undergoing physical examination during the same period served as the non-SS group. According to the presence of secondary ITP, patients were further divided into the ITP subgroup(n = 32) and the non-ITP subgroup(n = 110). Serum levels of Th17, Treg, Th17/Treg ratio, and IgA, IgM, IgG were compared among groups. Results Compared with the non-SS group, the SS group exhibited significantly higher Th17 percentage, Th17/Treg ratio, IgA and IgG, whereas Treg percentage was markedly lower(P<0.05). There was no significant difference in IgM between the two groups(P>0.05). The ITP subgroup showed further elevations in Th17 percentage, Th17/Treg ratio, IgA, IgG and IgM, along with a more pronounced reduction in Treg percentage, relative to the non-ITP subgroup(P<0.05). Conclusion SS patients complicated with ITP manifest prominent Th17/Treg imbalance and aberrant immunoglobulin profiles, which may serve as potential targets for clinical disease assessment.