β2-微球蛋白、尿白蛋白/肌酐比值及尿总蛋白水平与2型糖尿病患者肾病进展的价值分析

Objective To analyze the correlations between the levels of β2-microglobulin(β2-MG), urine albumin/creatinine ratio(ACR), and 24-hour urinary total protein(UTP) in patients with type 2 diabetic nephropathy(DN) and the progression of the disease. Methods From April 2023 to October 2024, 80 early-stage diabetic nephropathy patients were randomly selected from those treated in our hospital as the observation group. After 12 months of enrollment, patients were invited for follow-up visits to assess disease progression. Based on interstitial fibrosis and renal tubular atrophy(IFTA) growth, they were classified into the no-progression group(23 cases, with follow-up scores remaining at 0), low-progression group(39 cases, with follow-up scores at 1), and high-progression group(18 cases, with follow-up scores ≥2). β2-MG, ACR, and UTP levels were measured at enrollment, and differences among groups were observed. The predictive value of these indicators for worsening diabetic nephropathy was also examined. Results At both enrollment and follow-up, the comparison of β2-MG, ACR, and UTP among the three groups of patients showed statistically significant differences.(P<0.05). In the prediction analysis of DN progression, the AUC for each single indicator(β2-MG, ACR, UTP) exceeded 0.6, showing a certain correlation with patient progression. When combined, the AUC reached 0.873, demonstrating strong predictive efficacy for DN progression. Conclusion In the prediction of type 2 diabetic nephropathy progression, β2-MG, ACR, and UTP demonstrate good efficacy and can provide evidence for patient progression prediction.