计算机断层扫描联合肿瘤标志物检查在早期肺癌中的诊断价值

Objective To explore the application value of combined examination of computed tomography(CT) and tumor markers [carcinoembryonic antigen(CEA), tumor specific growth factor(TSGF), carbohydrate antigen 125(CA125), cytokeratin 19 fragment(CYFRA21-1)] in the diagnosis of early lung cancer. Methods A total of 80 patients with suspected early lung cancer admitted to Fuping County Hospital from October 2024 to October 2025 were enrolled. All patients underwent CT examination and detection of four tumor markers(CEA, TSGF, CA125, CYFRA21-1) after admission, with histopathological examination as the diagnostic gold standard. Among the enrolled patients, 44 cases were confirmed as early lung cancer and 36 cases as benign pulmonary lesions by the gold standard. The diagnostic efficacy of CT combined with the four tumor markers in early lung cancer was analyzed. Results In the clinical diagnosis of early lung cancer, the sensitivity, specificity and accuracy of combined CT and tumor markers detection were 95.45%(42/44), 97.22%(35/36) and 96.25%(77/80) respectively, which were higher than those of single CT examination [77.27%(34/44), 88.89%(32/36), 82.50%(66/80)] and single tumor markers detection [70.45%(31/44), 69.44%(25/36), 70.00%(56/80)]. All differences were statistically significant(P<0.05). Conclusion In the clinical diagnosis of early lung cancer, CT combined with the detection of CEA, TSGF, CA125 and CYFRA21-1 tumor markers can significantly improve diagnostic efficacy, which possesses high clinical application value.