双歧杆菌联合马来酸曲美布汀对结肠息肉患者术后的影响

Objective To explore the effect of bifidobacterium combined with trimebutine maleate on postoperative recurrence and intestinal flora in patients with colonic polyps. Methods A total of 98 patients with colonic polyps who underwent endoscopic resection in our hospital from March 2021 to March 2024 were divided into a control group(n=49) and an observation group(n=49) using a random number table method. Patients in the control group were given oral administration of trimebutine maleate tablets(0.1g per dose) three times a day for 4 weeks after surgery. Patients in the observation group were additionally given bifidobacterium, lactobacillus triple viable tablets(2g per dose) on the basis of the treatment for the control group, three times a day, taken orally for 4 weeks. Compared the recurrence rate of colonic polyps, the number of recurrent polyps, the maximum diameter, and the pathological classification between the two groups at 12 months after surgery, detected the levels of bifidobacterium, lactobacillus, enterococcus faecalis, and escherichia coli, and calculated the incidence of drug-related adverse reactions. Results Twelve months after the intervention, the recurrence rate of colonic polyps in the observation group was significantly lower than that in the control group, the number and maximum diameter of recurrent polyps were smaller, the incidence of adenomatous polyps was decreased(P<0.05). The level of lactobacillus in the observation group was significantly higher than that in the control group, while the level of escherichia coli was significantly lower than that in the control group(P<0.05). The total incidence of drug-related adverse reactions was comparable between the two groups, and the difference was not statistically significant(P>0.05). Conclusion The intervention of bifidobacterium combined with trimebutine maleate can effectively reduce the recurrence rate of colonic polyps after surgery, optimize the composition of the intestinal flora, and has good safety. It provides a novel multi-target intervention strategy for the prevention of recurrence after colon polyp surgery.