ISSN 2097-5724 CN 61-1535/R 主管·主办:陕西省疾病预防控制中心
疾病预防与控制 Disease Prevention and Control 医学学术期刊 双月刊
2026-03-031 临床药物与手术治疗 2026, 2(03): 121-124

瑞马唑仑对椎管内麻醉下泌尿外科手术患者术后恢复质量的影响

中国人民解放军联勤保障部队第九七〇医院 2.烟台市烟台山医院

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摘要

目的 探讨瑞马唑仑在椎管内麻醉下泌尿外科手术中的应用效果,为临床麻醉方案优化提供循证医学依据。方法 选取2024年6月至12月我院择期行椎管内麻醉的泌尿外科手术患者60例,随机分为瑞马唑仑组(R组)和空白对照组(C组),每组30例。通过中文版15项恢复质量(QoR-15)量表评估术后恢复质量,持续监测术中核心体温,统计围手术期低体温、寒战发生率及寒战严重程度。结果 R组术后第1天QoR-15评分显著高于C组(P<0.05);R组给药后15 min(T2)、30 min(T3)核心体温显著高于C组同期水平(P<0.05);R组围手术期低体温发生率(36.7%)、寒战发生率(10.0%)显著低于C组(66.7%、40.0%),且寒战以轻度为主,无重度寒战发生(P<0.05)。结论 瑞马唑仑可通过调节体温调节中枢功能、缓解术中焦虑、减轻应激反应,降低低体温及寒战发生风险,多维度提升术后恢复质量,且药代动力学优势确保临床安全性,具有重要推广价值。

Abstract

Objective To explore the application effect of remimazolam in urological surgeries under spinal anesthesia, and to provide evidence-based medical evidence for the optimization of clinical anesthesia plans. Methods Sixty patients who underwent elective spinal anesthesia in the urology department of our hospital from June to December 2024 were selected and randomly divided into the remimazolam group(Group R) and the blank control group(Group C), with 30 patients in each group. The quality of postoperative recovery was evaluated using the Chinese version of the 15-item Quality of Recovery Scale(QoR-15 scale). The core body temperature during the operation was continuously monitored, the incidence of perioperative hypothermia and shivering and severity of shivering were statistically analyzed. Results On the first day after surgery, the QoR-15 score of group R was significantly higher than that of group C(P<0.05), the core body temperatures of group R at 15 minutes(T2) and 30 minutes(T3) after administration were significantly higher than those of group C at the same time points(P<0.05), the incidence of perioperative hypothermia in group R(36.7%) and the incidence of shivering(10.0%) were significantly lower than those in group C(66.7% and 40.0%), and the shivering were mainly mild, without severe shivering(P<0.05). Conclusion Remimazolam can regulate the function of the body temperature regulation center, alleviate anxiety during surgery, reduce stress responses, lower the risk of hypothermia and shivering, improve the quality of postoperative recovery from multiple aspects, and its pharmacokinetic advantages ensure clinical safety. It has significant promotional value.

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[1]王辰宇,梁欢,刘志武.瑞马唑仑对椎管内麻醉下泌尿外科手术患者术后恢复质量的影响[J].疾病预防与控制,2026,2(03):121-124.