基于“天人相应”理论探讨昼夜节律与骨质疏松症的关系
广州中医药大学 2.广州中医药大学第三附属医院
在当前社会老龄化加剧的背景下,骨质疏松症(OP)已成为一个严峻的公共卫生问题。据最新流行病学数据显示,全球约有2亿人受骨质疏松症影响,其发病率在老年人群中逐年攀升。“天人相应”理论主张人体的生理机能和病理过程应当与自然界的周期性变化保持一致,强调了人类与自然界的和谐统一。天人相应理论通过分析昼夜更替等自然周期性变化揭示节律与疾病之间的关联。骨质疏松症的发生和进展与自然环境的变迁以及人体内部环境的失衡紧密相关。因此,维护人与自然的和谐统一,以及调整人体内部环境的平衡,对于预防和治疗骨质疏松症至关重要。本文旨在探讨“天人相应”理论与昼夜节律以及骨质疏松症之间的联系,并基于该理论提出了针对性的预防和治疗策略,为骨质疏松症的防治工作提供理论及实践指导。
Against the backdrop of the intensifying aging of society, osteoporosis(OP) has become a serious public health issue. According to the latest epidemiological data, approximately 200 million people worldwide are affected by osteoporosis, and its incidence rate is increasing year by year among the elderly population. The theory of “Correspondence Between Nature and Man” emphasizes the harmonious unity between humans and the natural world, suggesting that the physiological functions and pathological changes of the human body should be adapted to the rhythms of nature. This theory reveals the connection between rhythmic changes and the occurrence and development of diseases by analyzing the natural cyclical changes such as the alternation of day and night. It has profound implications for the prevention and treatment of chronic diseases. The occurrence and progression of osteoporosis are closely related to changes in the natural environment and the imbalance of the internal human environment. Therefore, maintaining harmony between humans and nature and balancing the internal environment of the human body are crucial for the prevention and treatment of osteoporosis. This paper aims to explore the connection between the theory of “Correspondence Between Nature and Man”, circadian rhythms, and osteoporosis, and proposes targeted prevention and treatment strategies based on this theory, providing a new perspective and methods for the field of osteoporosis prevention and treatment.
引用本文
按标准格式复制,或导出到文献管理软件参考文献
共 20 条- [1]Sabri SA,Chavarria JC,Ackert-Bicknell C,et al.Osteoporosis:An Update on Screening,Diagnosis,Evaluation,and Treatment[J]. Orthopedics,2023,46(1):e20-e26.
- [2]Swanson C. Sleep Disruption and Bone Health[J]. Curr Osteoporos Rep,2022,20(3):202-212.
- [3]Mei G,Wang J,Wang J,et al. The specificities,influencing factors,and medical implications of bone circadian rhythms[J]. FASEB J,2024,38(13):e23758.
- [4]马宏宇,刘炳义,武治彪,等.基于“天人相应”理论探析冠心病的中医时间医学内涵[J].实用中医内科杂志,2023,37(8):35-38.
- [5]姚怡,王庆其.当代《黄帝内经》学术思想体系研究及其启示[J].中国中医基础医学杂志,2017,23(11):1501-1503.
- [6]黄佳纯,黄宏兴,万雷,等.脾肾-肌骨-线粒体理论探析[J].中国骨质疏松杂志,2021,27(12):1844-1847.
- [7]Zhang W,Xiong Y,Tao R,et al. Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence[J]. Front Endocrinol(Lausanne),2022,13:915139.
- [8]Li T,Zhang S,Yang Y,et al. Co-regulation of circadian clock genes and microRNAs in bone metabolism[J]. J Zhejiang Univ Sci B,2022,23(7):529-546.
- [9]Cizza G,Ronsaville DS,Kleitz H,et al. Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women:the power study[J]. PLoS One,2012,7(1):e28912.
- [10]Zdrojowy-Welna A,Stachowska B,Bolanowski M.Cushing’s disease and bone[J]. Pituitary,2024,27(6):837-846.
- [11]Kennaway DJ,Voultsios A,Varcoe TJ,et al.Melatonin in mice:rhythms,response to light,adrenergic stimulation,and metabolism[J]. Am J Physiol Regul Integr Comp Physiol,2002,282(2):R358-R365.
- [12]Maria S,Samsonraj RM,Munmun F,et al. Biological effects of melatonin on osteoblast/osteoclast cocultures,bone,and quality of life:Implications of a role for MT2 melatonin receptors,MEK1/2,and MEK5 in melatonin-mediated osteoblastogenesis[J]. J Pineal Res,2018,64(3):10.1111/jpi.12465.
- [13]Ochs-Balcom HM,Hovey KM,Andrews C,et al.Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women’s Health Initiative[J]. J Bone Miner Res,2020,35(2):261-268.
- [14]于海霞,尤瑞金,杨芸,等.绝经后妇女睡眠质量指标与骨密度的关系研究[J].医学综述,2021,27(11):2284-2288.
- [15]Feskanich D,Hankinson SE,Schernhammer ES.Nightshift work and fracture risk:the Nurses’ Health Study[J]. Osteoporos Int,2009,20(4):537-542.
- [16]Religi A,Backes C,Chatelan A,et al. Estimation of exposure durations for vitamin D production and sunburn risk in Switzerland[J]. J Expo Sci Environ Epidemiol,2019,29(6):742-752.
- [17]Yan J,Wang J,Chen J,et al. Adjusting phosphate feeding regimen according to daily rhythm increases eggshell quality via enhancing medullary bone remodeling in laying hens[J]. J Anim Sci Biotechnol,2023,14(1):17.
- [18]Gardinier JD,Mohamed F,Kohn DH. PTH Signaling During Exercise Contributes to Bone Adaptation[J]. J Bone Miner Res,2015,30(6):1053-1063.
- [19]东智卓玛,杨彬彬,林适,等.壮骨强肌方对去势大鼠骨密度及IL-17的影响[J].中国骨质疏松杂志,2024,30(1):62-69.
- [20]胡阳,金宇.老年性骨质疏松症患者施用子午流注纳支法穴位敷贴的疗效分析[J].中国骨质疏松杂志,2017,23(6):768-771.
| 文章编号 | 2026-02-054(期号内编号) |
|---|---|
| 栏目 | 中医学研究 |
| 作者 | 梁晓敏1;卢文彬1;钟巍1;黄佳纯1;万雷2;黄宏兴2;张志海2 |
| 作者单位 | 广州中医药大学 2.广州中医药大学第三附属医院 |
| 通信邮箱 | 13725295793@139.com; |
| 基金项目 | 广东省科技计划省社会发展科技协同创新体系建设项目(2024A1111120018); 广东省基础与应用基础研究基金企业联合基金重点项目(2023B1515230001) |
| 中图分类号 | R259 |
| 卷期页码 | 2026, 2(02): 213-216 |
| 发布时间 | 2026-03-15 |
| 出版时间 | 2026-03-15 |
| 引用信息 | [1]梁晓敏,卢文彬,钟巍,等.基于“天人相应”理论探讨昼夜节律与骨质疏松症的关系[J].疾病预防与控制,2026,2(02):213-216. |
| 全文地址 | 在知网查看该文(kns.cnki.net) |
| 数据抓取时间 | 2026-09-22T12:23:19 |