持续气道正压无创呼吸机治疗小儿重症肺炎并发急性呼吸衰竭的临床效果观察

Abstract: Objective To investigate the clinical efficacy of continuous positive airway pressure (CPAP) non-invasive ventilator therapy in children with severe pneumonia complicated by acute respiratory failure, focusing on its effects on clinical indicators, treatment outcomes, and complications. Methods A total of 84 children with severe pneumonia and acute respiratory failure were randomly divided into two groups: the control group (n=42) received conventional oxygen therapy and symptomatic supportive treatment, while the observation group (n=42) received the same conventional symptomatic supportive treatment as the control group, plus additional CPAP non-invasive ventilator therapy. Differences in blood gas indices, respiratory function, immune-inflammatory markers, and overall efficacy were compared to evaluate the optimal treatment approach. Results After 7 days of treatment, the blood gas indexes of the observation group were significantly better than those of the control group, the respiratory rate and respiratory distress scores were significantly lower than those of the control group, the c-reactive protein, white blood cell count and interleukin-6 (IL-6) cytokine levels were significantly lower than those of the control group, and the total effective rate was significantly higher than that of the control group. The incidence of complications and the conversion rate of mechanical ventilation were significantly lower than those in the control group (P＜0.05). Conclusion CPAP non-invasive ventilator therapy, as a non-invasive respiratory support technique, achieved remarkable clinical effects in treating children with severe pneumonia complicated by acute respiratory failure. This treatment method significantly improves blood gas indicators and respiratory function, reduces systemic inflammatory response, enhances overall efficacy, and decreases the incidence of complications and mechanical ventilation conversion rate. Therefore, CPAP therapy has high potential for promotion and broad application prospects in this patient population.