人类表皮生长因子受体2高表达结直肠癌的病理特征及预后影响

Objective To investigate the clinicopathdogical characteristics of colorectal cancer with high expression of human epidermal growth factor receptor2(HER2) and its impact on the prognosis of patients with colorectal cancer. Methods 86 cases of colorectal cancer admitted to Alar Hospital of the first division of Xinjiang Production and Construction Corps from 2021 to 2024 were selected as the research objects. According to HER2 immunohistochemistry and FISH detection results, they were divided into HER2 high expression group(9 cases) and HER2 low expression group(77 cases). The differences in gender, age, tumor location, size, depth of invasion, lymph node metastasis, distant metastasis, histological grade and clinical stage between the two groups were analyzed. The prognosis of patients with colorectal cancer was compared between the two groups. Results In 86 patients with colorectal cancer, the incidence of 10.5%(9/86) with high expression of HER2 was lower than 89.5%(77/86) with low expression of HER2. Compared with patients with HER2 low expression colorectal cancer, patients with HER2 high expression colorectal cancer had higher depth of invasion, pathological grade, lymph node metastasis, distant metastasis rate, and relatively higher malignant degree(P<0.05). There was no significant difference in gender, age and tumor size between the two groups(P>0.05). The overall survival rate of patients with high HER2 expression was lower than that of patients with low HER2 expression(P<0.05). The cumulative risk of colorectal cancer was higher in patients with HER2-high expression than in those with HER2-low expression. Conclusion Colorectal cancer with high HER2 expression has a low proportion. Compared with low expression of HER2, colorectal cancer with high expression of HER2 has deeper invasion, higher risk of metastasis and later clinical stage, and the prognosis of patients is poor.