糖化血红蛋白与血脂谱评估糖尿病代谢综合征风险的研究

Abstract: Objective To explore the correlation between glycated hemoglobin (HbA1c) and the levels of blood lipids and lipoproteins in patients with type 2 diabetes mellitus (T2DM), and to evaluate its clinical application value in diabetes diagnosis and condition assessment. Methods A total of 312 subjects, including those who received health check-ups in the outpatient department and inpatients with type 2 diabetes mellitus in our hospital from January 2023 to December 2023, were selected. Among them, 156 cases had normal glucose metabolism (normal glucose tolerance group, NGT group) and 156 cases were patients with type 2 diabetes mellitus (T2DM group). Indicators such as glycated hemoglobin (HbA1c), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were detected in both groups. The differences in various indicators between the two groups were compared, and the correlation between HbA1c and blood lipid indicators was analyzed. Results Compared with the NGT group, the levels of HbA1c, FBG, TC, TG, and LDL-C in the T2DM group were significantly increased, while the level of HDL-C was significantly decreased, with statistically significant differences (P＜0.05). Correlation analysis showed that HbA1c level was positively correlated with FBG, TC, and TG, and negatively correlated with HDL-C. Conclusion HbA1c level is closely related to blood glucose and lipid metabolism. The combined detection of HbA1c, TC, TG, HDL-C, and LDL-C is helpful to improve the diagnostic accuracy of diabetes and the comprehensiveness of condition assessment, which has important clinical significance.