宫颈环形电切术对妊娠结局影响的病例分析

Abstract: Objective To investigate the effect of the time interval between cervical circular electrosurgical excision procedure (LEEP) and the first pregnancy on pregnancy outcomes and delivery methods. Methods Collect pregnant women who received LEEP treatment for high-grade squamous intraepithelial lesions of the cervix at Weinan Central Hospital in Shaanxi Province from January 1, 2020 to December 31, 2023 as the observation group (n=102), and randomly select healthy pregnant women who gave birth at the same time as the control group (n=103). Analyze and compare the incidence of adverse pregnancy outcomes between the observation group and the control group, as well as the incidence of adverse pregnancy outcomes at different postoperative to pregnancy time intervals in the observation group. Results The incidence of miscarriage and premature birth in the observation group was higher than that in the control group (χ2 =7.464, P=0.006. χ2 =4.986, P=0.026). The human papillomavirus (HPV) seroconversion rate of 102 patients in the observation group after LEEP surgery was 60% for patients ＜6 months and 98.15% for patients ≥24 months, there was a statistical difference in HPV seroconversion rates between different postoperative times (χ 2 =8.541, P=0.036). There were statistically significant differences in the rates of miscarriage and premature birth among patients with different postoperative to pregnancy time intervals (P＜0.05). The incidence of low birth weight infants in the group with a time interval of ＜12 months between surgery and pregnancy was higher than that in the groups with a time interval of 12～＜24 months and ≥24 months (χ2 =12.307, P=0.006). Conclusion LEEP surgery may increase the risk of miscarriage and premature birth, and the incidence of adverse pregnancy outcomes such as miscarriage and premature birth is significantly higher in patients with a time interval of less than 12 months from LEEP surgery to their first pregnancy.