辅酶 Q10 治疗氟乙酰胺中毒患者心肌损伤的效果分析

Objective This study aimed to investigate the effect of coenzyme Q10 on cardiac dysfunction in patients with fluoroacetamide poisoning and evaluate its efficacy in myocardial injury and clinical recovery. Methods Twenty-five patients with fluoroacetamide poisoning admitted to Jiamusi Central Hospital and Fujin Central Hospital between June 2023 and September 2024 were randomly divided into a control group (n=10) and an observation group (n=15). Both groups received basic treatment, while the observation group additionally received coenzyme Q10 for 7 days. Primary outcomes included symptom improvement time, hospitalization duration, myocardial injury markers, and cardiac function parameters. Results The observation group showed significantly shorter symptom improvement time (4.800±0.775) days and hospitalization duration (8.800±0.775) days compared to the control group (6.900±0.738, 11.900±0.738) days; (P＜0.05). Myocardial injury markers-cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase-MB isoenzyme (CK-MB), and N-terminal pro-B-type natriuretic peptide (NTpro-BNP)were significantly lower in the observation group (P＜0.05). Echocardiography revealed significantly higher left ventricular ejection fraction (LVEF) (60.667%±1.175%) and lower left ventricular end-systolic diameter (LVESD) (5.013±0.146 cm) in the observation group versus the control group (51.000%±1.826%, 5.600±0.183 cm; P＜0.05). Conclusion Coenzyme Q10 combined therapy significantly improves myocardial injury and cardiac dysfunction in fluoroacetamide-poisoned patients, demonstrating superior efficacy to conventional acetamide treatment alone.