回顾性研究慢性乙型肝炎患者APRI指数与超声肝包膜粗糙度的相关性

Objective To retrospectively study the correlation between aspartate aminotransferase(AST)/platelet ratio index(APRI) and ultrasound hepatic envelope roughness in patients with chronic hepatitis B(CHB), and to assess the predictive value of APRI for liver fibrosis. Methods A cross-sectional study was used to include 80 patients with CHB who did not receive antiviral therapy, AST and platelet counts were detected to calculate APRI, ultrasound was used to assess hepatic envelope roughness grading(grade 0～3), and Siemens ultrasound liver stiffness all-in-one machine was used to determine liver stiffness value(LSM). Pearson correlation analysis, ROC curve and multiple regression were used to analyze the data. Results APRI was significantly and positively correlated with hepatic envelope roughness grading(r=0.732, P<0.001). APRI ≥1.05 predicted hepatic envelope roughness grade ≥2 with a sensitivity of 89.5% and a specificity of 68.2%(AUC=0.843). Multifactorial regression showed APRI(β=0.682, P<0.001) and LSM(β=0.214, P=0.015) were independent influences. Conclusion APRI can effectively assess the degree of liver fibrosis in patients with CHB, combined with ultrasonography can improve the diagnostic accuracy, and antiviral treatment can significantly improve the level of APRI.