结直肠癌根治术标本中IGF-1R与炎症因子表达及与肿瘤侵袭转移的关联研究

Objective To explore the association between the expression of insulin-like growth factor 1 receptor(IGF-1R) and inflammatory factors in radical resection specimens of colorectal cancer(CRC), as well as its correlation with tumor invasion and metastasis. Methods A study was conducted on 120 patients who underwent radical resection for CRC at Funing County People's Hospital from January 2022 to December 2025. Cancer tissues and adjacent normal tissues of the patients were collected, and the expression of IGF-1R and inflammatory factors in different tissues was detected and compared. The patients were divided into the metastasis group(n=35) and the non-metastasis group(n=85) based on whether tumor invasion and metastasis occurred. The pathological characteristics and expression of IGF-1R and inflammatory factors were compared between the two groups. Multivariate Logistic regression analysis was used to clarify the influencing factors of tumor invasion and metastasis in patients undergoing radical resection for CRC. Results The positive rates of IGF-1R, TNF-α, and IL-6 in CRC tissues were higher than those in adjacent normal tissues(P<0.05). The metastasis group had lower differentiation, TNM stage of Ⅲ-Ⅳ, and higher proportions of patients with positive IGF-1R, TNF-α, and IL-6 compared with the non-metastasis group(P<0.05). There was no statistically significant difference in gender, age and body mass index between the two groups of patients(P>0.05). Multivariate Logistic regression analysis confirmed that the independent risk factors for tumor invasion and metastasis in patients undergoing radical resection for CRC were low differentiation, stage Ⅲ-Ⅳ, positive IGF-1R, positive TNF-α, and positive IL-6(P<0.05). Conclusion The expressions of IGF-1R, TNF-α, and IL-6 are closely related to tumor invasion and metastasis in CRC patients.