雷贝拉唑联合胶体果胶铋对胃溃疡合并胃黏膜糜烂患者黏膜屏障功能及炎性因子的影响

Objective To investigate the effects of rabeprazole combined with colloidal bismuth pectin on mucosal barrier function and inflammatory cytokines in patients with gastric ulcer complicated with gastric mucosal erosion. Methods A total of 80 patients with gastric ulcer complicated with gastric mucosal erosion admitted to the Department of Gastroenterology of Yuncheng City Hospital of Traditional Chinese Medicine from January 2023 to March 2026 were selected and randomly divided into control group(rabeprazole monotherapy) and observation group(rabeprazole combined with colloidal bismuth pectin), with 40 cases in each group. The gastric mucosal healing effects, mucosal barrier function indicators [pepsinogen Ⅰ(PGⅠ), pepsinogen Ⅱ(PGⅡ), and PGⅠ/PGⅡ ratio], inflammatory cytokine levels [interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), and interleukin-2(IL-2)], and adverse reactions were compared between the two groups before and after treatment. Results The total effective rate of the observation group was higher than that of the control group(P<0.05). After treatment, both groups showed an increase in PGⅠ and PGⅠ/PGⅡ ratio, with the observation group being higher than the control group(P<0.05). The levels of IL-6 and TNF-α decreased in both groups, while the level of IL-2 increased(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Rabeprazole combined with colloidal bismuth pectin can effectively promote ulcer healing, improve gastric mucosal barrier function, and alleviate inflammatory responses in patients with gastric ulcer complicated with gastric mucosal erosion, with a favorable safety profile.