集采政策下抗菌药物在临床实践中的疗效与安全性评价

Objective This study aimed to evaluate the efficacy and safety of selected antibiotics before and during centralized procurement in clinical practice. Methods Retrospective analysis method was used to randomly selected 50 patients who used moxifloxacin sodium chloride injection, ceftriaxone sodium for injection, cefoperazone sodium for injection and sulbactam sodium for injection, piperacillin sodium and tazobactam sodium for injection in our hospital in January 2019 and January 2023, respectively, and they were classified into two groups before and after collection. The inflammatory indexes of white blood cell(WBC), neutrophil percentage(NEUT%), C-reactive protein(CRP), procalcitonin(PCT), interleukin-6(IL-6), symptom improvement time, treatment dose and course of treatment, treatment efficiency, bacterial clearance rate and incidence of adverse reactions were compared before and after treatment. Results There was no significant difference in the effective rate, bacterial clearance rate and incidence of adverse reactions between the two groups before and after collection. Conclusion The clinical efficacy and safety of centralized drug collection are similar to those before centralized drug collection, which can provide basis for clinical rational drug use and resource optimization.