莫沙必利对重症脓毒症患者胃肠功能障碍改善价值研究

Objective To analyze the effect of mosapride intervention on gastrointestinal dysfunction in patients with severe sepsis. Methods A total of 86 patients with severe sepsis complicated with gastrointestinal dysfunction collected in our hospital from March 2024 to October 2025 were selected and randomly divided into two groups. The control group received conventional treatment of sepsis combined with conventional gastrointestinal treatment, and the observation group received mosapride intervention on the basis of the control group. The gastrointestinal function indexes, gastrointestinal motility related markers, inflammatory factor levels, hospitalization indexes and adverse reactions of the two groups were analyzed. Results The improvement of gastrointestinal function indexes in the observation group was better than that in the control group(P<0.05). The gastrointestinal motility related markers in the observation group were significantly increased after the intervention(P<0.05), and the indexes related to the level of inflammatory factors in the observation group were significantly decreased(P<0.05). The hospitalization time and mechanical ventilation time in the observation group were shorter(P<0.05), and there was no significant difference in adverse reactions incidence between the two groups(P>0.05). Conclusion Mosapride intervention in patients with severe sepsis can effectively promote the recovery of gastrointestinal function, reduce the level of inflammation, shorten the length of hospital stay, and has good safety.