多指标联合检测对肺结核早期诊断的价值分析

Objective To analyze the value of multi-index combined detection in the early diagnosis of pulmonary tuberculosis. Methods A retrospective analysis was conducted on the clinical data of 102 patients with pulmonary tuberculosis who were treated in our hospital from 2021 to 2022. These patients were included in the pulmonary tuberculosis group. Another 102 healthy individuals who underwent physical examinations in our hospital during the same period were selected and included in the healthy group. All groups underwent tests for inflammatory factor levels, blood routine, electrolytes, liver function, coagulation function, and cardiac function indicators. The test results of the two groups were compared. A multivariate Logistic regression model was used to analyze the combined predictive factors, and the ROC curve was used to analyze the diagnostic value of combined detection of multiple indicators for pulmonary tuberculosis. Results The levels of C-reative protein(CRP), procalcitonin(PCT), erythrocyte sedimentation rate, hematocrit(HCT), neutrophil to lymphocyte ratio(NLR), potassium(K), adenosine deaminase(ADA), d-dimer(D-D), fibrinogen(FIB) and B-type brain natriuretic peptide(BNP) in the pulmonary tuberculosis group were higher than those in the healthy group(P<0.05). The results of multivariate Logistic regression analysis showed that CRP, NLR, ADA, and D-D were variables with independent predictive significance(P<0.05). The results of ROC curve analysis showed that CRP had an AUC of 0.903 for the diagnosis of pulmonary tuberculosis. The optimal cut-off value was 21.542. NLR had an AUC of 0.934 for the diagnosis of pulmonary tuberculosis. The optimal cut-off value was 4.255. ADA had an AUC of 0.892 for the diagnosis of pulmonary tuberculosis. The optimal cut-off value was 18.604. D-D had an AUC of 0.912 for the diagnosis of pulmonary tuberculosis. The optimal cutoff value was 1.121. The combined detection had an AUC of 0.967 for the diagnosis of pulmonary tuberculosis. The optimal cut-off value was 0.573. Conclusion For the early diagnosis of pulmonary tuberculosis, the use of multi-index combined testing has a good diagnostic value and can provide a reference for clinical diagnosis and treatment.