等效均匀剂量在腹部肿瘤调强放射治疗中的临床应用研究

Objective To investigate the clinical efficacy of equivalent uniform dose in intensity-modulated radiotherapy(IMRT) for abdominal tumors. Methods A total of 56 patients with abdominal tumors undergoing IMRT at our hospital were enrolled from February 2024 to February 2025. Using the Elekta Monaco treatment planning system, two IMRT plans were developed based on different optimization methods, the control group received traditional dose-volume physical optimization(n=28), while the observation group adopted equivalent uniform dose biological optimization(n=28). The dosimetric differences between the two optimization methods were compared. Results There were no significant differences in the mean dose(Dmean), 95% target volume dose(D95%), 5% target volume dose(D5%), or unit intensity(UI) between the two groups(P>0.05). The observation group showed a higher clinical index(CI) compared to the control group(P<0.05). The observation group demonstrated statistically significant reductions in small intestine Dmean, D2%, and volumes receiving 15 Gy, 30 Gy, and 45 Gy doses(V15, V30, V45)(P<0.05). The bladder in the observation group exhibited lower Dmean and volumes receiving 30 Gy and 40 Gy doses(V30, V40)(P<0.05). Additionally, the left and right kidneys in the observation group showed statistically significant reductions in Dmean and volumes receiving 15 Gy and 30 Gy doses(V15, V30)(P<0.05). Conclusion The bio-optimization of equivalent uniform dose can effectively improve the dose distribution, increase the conformity of target area and significantly reduce the dose of surrounding normal tissues in the abdominal tumor IMRT.