布托啡诺与盐酸纳布啡对剖宫产产妇血流动力学的影响

Objective To explore the effects of butorphanol and nalbuphine hydrochloride on hemodynamics and the occurrence of chills in postoperative analgesia of parturients undergoing cesarean section under combined spinal-epidural anesthesia. Methods The study samples were selected from the pregnant women who were admitted to our hospital from July 2023 to April 2025. A total of 62 cases were planned to have cesarean section under combined spinal and epidural anesthesia. Then they were grouped according to the random number table(butorphanol group and nabufine hydrochloride group), with 31 cases each. After the operation, the pregnant women were continuously administered with intravenous analgesia pump. Hemodynamics [heart rate(HR), mean arterial pressure(MAP), blood oxygen saturation(SpO2)] and pain [visual analogue scale(VAS)] were measured at 1 h(T1), 6 h(T2), 12 h(T3), and 24 h(T4) after surgery in the two groups, and the incidence of chills 24 h after surgery was compared between the two groups. Results At T1, there was no difference in hemodynamic indicators between the two groups(P>0.05). At T2～T4, the levels of HR and MAP in the butorphanol group were lower than those in the nalbuphine hydrochloride group(P<0.05). The SpO2 level was higher than that in the nalbuphine hydrochloride group(P<0.05). The VAS scores of T1～T4 in the butorphanol group were all lower than those in the nalbuphine hydrochloride group(P<0.05). The incidence of chills 24 hours after surgery in the butorphanol group was lower than that in the nalbuphine hydrochloride group(P<0.05). Conclusion Compared with nalbuphine hydrochloride, butorphanol is more helpful in maintaining the hemodynamic stability of parturients undergoing cesarean section under combined spinal-epidural anesthesia for postoperative analgesia, reducing postoperative pain and lowering the incidence of chills.